Search Tag: septic shock
2023 13 Oct
Vasopressin and landiolol are critical therapies for ensuring the vascular and cardiac systems are as close to optimal conditions as possible during septic shock. Better cardiovascular management in septic shock can help improve septic shock management. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response...Read more
2023 12 Sep
A woman came to see me a few days ago: her 44-year-old husband recently died from sepsis in another hospital, and she wanted to have a discussion about this tragic story. Her husband had had just some kind of blister on his foot. He didn’t seem very ill when he arrived at the hospital, but he quickly developed an extended area of fasciitis on his left...Read more
2023 09 May
A new study assessed the impact of high mean arterial pressure (MAP) on renal outcomes in critically ill cirrhosis patients with septic shock (CIC). The efficacy of a high MAP strategy (80-85 mm Hg; H-MAP) was compared to a low MAP strategy (60-65 mm Hg; L-MAP) in improving 28-day mortality in CIC. Additionally, the study examined the reversal of shock,...Read more
2022 16 Mar
Sepsis is a leading cause of morbidity and mortality in the intensive care unit. Nearly 14 million adults and 2.5 million children survive sepsis each year worldwide. In addition, sepsis survivors are known to experience poor long-term outcomes and often develop functional limitations thereafter. It is thus evident that the long-term impact...Read more
2022 16 Mar
An overview of vasopressor management, current evidence and when to initiate vasopressor therapy for best possible patient outcome. Vasopressor management is a cornerstone in the haemodynamic management of septic shock for reversing hypotension by increasing systemic vascular resistance and improving organ perfusion. The Surviving Sepsis Campaign...Read more
2022 16 Mar
An overview of the haemodynamic management of patients in septic shock and strategies for detection of haemodynamic changes and appropriate therapeutic action to improve the prognosis of these patients. Introduction Sepsis is one of the main causes of admission to the Intensive Care Unit (ICU). It is defined as a life-threatening organ...Read more
2022 15 Feb
Approximately 85,000 patients are admitted to the emergency department in the U.S. each year for sepsis or septic shock. The Surviving Sepsis Campaign (SSC) has established International clinical practice guidelines for managing these patients. The guidelines consist of a bundle that includes treatments for various components of sepsis, including rapid...Read more
2022 01 Feb
Sepsis is a life threatening condition with an estimated 49 million cases worldwide and 11 million deaths. It involves organ dysfunction due to a dysregulated host response to infection. Sepsis continues to be a global health issue and is is responsible for approximately 20% of annual global deaths. Sepsis is typically managed through intravenous...Read more
2021 09 Nov
Acute respiratory failure in septic patients is associated with higher in-hospital mortality. Early management and treatment with antibiotics, fluids, vasopressors, and source control, can reduce morbidity and mortality. Sepsis-related acute respiratory failure is also frequent and may require non-invasive or invasive ventilator support. While...Read more
2021 05 Oct
Findings from the COMPACT-2 trial were presented today at #LIVES2020. The study evaluated the efficacy and safety of high dose (> 0.2 L/kg of treated plasma per day) coupled plasma filtration-adsorption (CPFA) in treating patients with septic shock. The study was performed in 12 Italian ICUs and enrolled patients aged 14 or more who were admitted...Read more
2021 24 Jun
This article summarises the proceedings of an ESICM webinar in which two experts discuss vasopressor therapy and its fundamental role in the treatment of septic shock-induced hypotension. They provide an overview of severe septic shock, the benefits of second-line vasopressors and their use in COVID-19 patients. Vasopressors in Severe Septic...Read more
2021 19 May
Incidence of sepsis and septic shock has been increasing consistently, and the morbidity and mortality associated with this is an area of concern. Mortality from sepsis and septic shock is quite high, ranging between 20 to 40%. Guidelines for sepsis and septic shock recommend the application of broad-spectrum antibiotics. There is clinical evidence...Read more
2021 05 May
Researchers Found That O3 May Help Clinicians Rapidly Assess Circulatory Status in Patients Experiencing Septic Shock and Have Prognostic Value in Mortality Prediction NEUCHATEL, Switzerland--(BUSINESS WIRE)-- Masimo (NASDAQ: MASI) announced today the findings of a study published in the Journal of Anesthesia & Clinical Research in which Dr....Read more
2020 24 Nov
Hypotension during septic shock is a strong indicator of patient outcome and mortality. Arginine vasopressin is a naturally produced human hormone with vasoconstriction effect via V1 receptor activation and a short 5-20 minutes half-life and is recommended by the Surviving Sepsis Campaign guidelines to be added as a second-line vasoactive agent when...Read more
2020 14 Sep
Sepsis and septic shock are the leading causes of death in the ICU. With an estimated mortality rate of 40-60%, septic shock is in the focus of adult critical care medicine. It is broadly accepted that intervention in the very early phase of sepsis before the complex inflammatory host response is initiated should be one major area that clinical research...Read more
2020 03 Feb
Initial fluid resuscitation practices for patients with haemodynamic shock remain controversial. There is significant variability in these practices, and the impact of this is still poorly understood. Overall, non-patient-centred resuscitation practices, conflicting treatments, variability, and failure to meet targets for initial resuscitation are...Read more
2020 22 Jan
Sepsis is a life-threatening condition that causes nearly one-third to half of all hospital deaths. It is also responsible for more than 5 million deaths worldwide each year. Patients with septic shock are an important subgroup of sepsis. These patients have circulatory and metabolic abnormalities that further increase their mortality risk. New treatments...Read more
2019 28 Dec
As we move into 2020, here's a quick recap of our most clicked stories in ICU in 2019: Using Biomarkers for Mortality Prediction in Patients With Sepsis A new study evaluated the prognostic value of six biomarkers at onset of sepsis in adult patients with sepsis or septic shock. Risk Factors for Frailty and Death in the ICU...Read more
2019 01 Dec
Septic shock is a serious illness that is associated with high morbidity and mortality. A significant number of patients who develop septic shock also have a number of comorbidities that further worsens the prognosis. Over the years, many studies have been published on the benefits of corticosteroids in patients with septic shock. Most of these...Read more
2019 23 Nov
Sepsis has always carried high mortality. Even today, with all the latest technology and newer antibiotics, sepsis continues to be a major risk factor for death. It is important to understand that the earlier sepsis is diagnosed and treated, the better the prognosis. Each year, nearly 6 million people die of sepsis in the US. Because of its aggressive...Read more
2019 14 Nov
Over the last few years, many advances have been made in the critical care of patients with septic shock. Both diagnosis and treatment strategies have improved. However, the mortality rates of patients with septic shock have a bimodal distribution; some patients die within a few days from it, while others die a few weeks later from other comorbidities. ...Read more
2019 21 Oct
Sepsis is a major cause of death among hospitalised patients. It affects nearly 6% of all admissions and results in in-hospital mortality of greater than 15%. Early detection could reduce mortality, as it would result in the timely implementation of evidence-based interventions. Clinical researchers have developed and implemented a machine-learning...Read more
2019 03 Jun
On Day 2 of the Euroanaesthesia Congress 2019 (#EA19), there was a session on Resuscitation in septic shock: is less better? Three key speakers Gernot Marx (Aachen, Germany), Claude Martin (Marseille, France) and Jean-Louis Vincent (Brussels, Belgium), spoke about less fluid, less vasopressors and less inotropes in septic shock. The central message...Read more
2019 23 Apr
Sepsis remains the most common cause of vasodilatory shock worldwide. The mainstay of haemodynamic treatment of septic shock is fluid resuscitation followed by vasopressors where fluids alone are insufficient to achieve target blood pressure. This article, published in the journal Critical Care, proposes the concept of “broad spectrum vasopressors”...Read more
2019 18 Mar
A Chinese research team performed a meta-analysis and trial sequential analysis of randomised controlled trials (RCTs) evaluating the effects of vasopressin receptor agonists in septic shock patients. Their findings show the use of vasopressin might result in reduced mortality in these patients, but an increased risk of digital ischaemia must be taken...Read more
2019 27 Feb
Among patients with septic shock, a resuscitation strategy targeting normalisation of capillary refill time, compared with a strategy targeting serum lactate levels, did not reduce all-cause 28-day mortality. These findings from the ANDROMEDA-SHOCK randomised clinical trial do not support the use of a peripheral perfusion-targeted resuscitation strategy...Read more