Search Tag: precision medicine
2021 14 Sep
Our population is ageing, and with increasing longevity, the prevalence of chronic conditions is also increasing. Multimorbidity is thus becoming a major challenge in the world of critical care. Multimorbidity refers to the co-occurrence of two or more chronic conditions in an individual. The combination of certain diseases in patients can trigger...Read more
2021 20 Jul
ARDS is a heterogeneous syndrome rather than a distinct disease. It is this heterogeneity that often makes it difficult to study treatments for patients with ARDS. Literature on ARDS is rife with clinical trials that do not show any mortality benefit. Recent evidence suggests different sub-phenotypes within the heterogeneous patient population....Read more
2021 18 May
Precision medicine has been an important goal in healthcare. Researchers have been focused on generating new disease subclassifications to maximise individualised treatment options. There have been many phenotypes, endotypes, and subtypes so that patients who demonstrate specific symptoms and fall into a specific subtype or phenotype can be treated...Read more
2020 15 Jan
Critical Care Medicine has existed for many years, but was only recognised as a specialty in the last 40 years or so. However, during this time, there has been a tremendous amount of change. Over the years, our understanding of different critical illnesses has improved, and our treatment strategies have become more effective. Technology has also played...Read more
2020 15 Jan
Over the next 50 years, critical care will evolve from a system that reacts to patient deterioration into a system that predicts and prevents these events. The application of real-time analytics to large-scale integrated ICU patient data will facilitate creation of learning healthcare systems and delivery of personalised and even predictive critical...Read more
2017 16 Mar
The specialty of intensive care medicine grew out of the realisation that critically ill patients needed more attention and specialised treatment than could be provided on a general ward, and that many of these patients had similar clinical problems and processes, so management would be facilitated if they were grouped together in one place. Since...Read more
2017 16 Mar
Multiple failed clinical trials testing immunomodulatory therapies for sepsis argue for a new approach. While precision medicine has been successfully implemented in other fields, testing it in sepsis poses challenges, which this review will discuss, along with potential implementation strategies. Sepsis has an estimated annual incidence of 1.3...Read more
2017 16 Mar
The progress towards, and potential of, personalised/ precision medicine in intensive care is the theme for our cover story. We are making progress in moving away from therapies based on poorly characterised patient populations to more personalised treatment of critically ill patients, although true precision medicine, based on individual genes, environment...Read more
2015 26 Oct
Scientists at Ecole Polytechnique Federale de Lausanne (Switzerland) have developed a miniature device that can monitor in real time five vital substances for patients in the intensive care unit. This means medical staff can be alerted about critical blood levels of patients and react more quickly. The device was unveiled at the 2015 BioCAS Conference...Read more