Search Tag: aspirin

ICU Management

#ISICEM22: The Place of Antiplatelet Agents in COVID-19 (REMAP-CAP Trial)

2022 22 Mar

Thrombotic events are common in patients hospitalised with COVID-19. Platelet activation has been implicated in the COVID-19 inflammatory response. However, the efficacy of antiplatelet therapy in critically ill patients with COVID-19 is still uncertain.  The Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia... Read more

ICU Management

RECOVERY Trial: Use of Aspirin in Patients With COVID-19

2021 14 Dec

The use of aspirin has been proposed as a treatment for COVID-19 because of its anti-thrombotic properties. Thrombosis is a key feature of COVID-19, with 5-30% of hospitalised patients having a major venous thromboembolic event and up to 3% having an arterial thromboembolic event.   The Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial is... Read more

IT Management

Smartphone App Could Improve Aspirin Use in Preeclampsia

2021 31 Oct

Hypertension disorder in pregnancy, preeclampsia, affects about 1 in every 20 pregnancies globally and usually appears after 20 weeks of gestation. Taking low-dose aspirin can help prevent preeclampsia, but this prophylactic treatment is underused among high-risk patients. A communication gap between providers and patients is one likely cause examined... Read more

Cardiology Management

Aspirin No Longer Effective as Primary Prevention for CVD

2019 16 Dec

A new paper in Family Practice, published by Oxford University Press, found that the widespread use of statins and cancer screening technology may have altered the benefits of aspirin use. Researchers concluded that aspirin no longer provides a net benefit as primary prevention for cardiovascular disease and cancer. Nearly half of adults 70 years... Read more

Cardiology Management

Aspirin in Primary Prevention

2019 01 Dec

Aspirin (acetylsalicylic acid) has the unique ability to to irreversibly acetylate serine in the active site of cyclo-oxygenase (COX), permanently blocking its action in prostaglandin synthesis. This results in analgesic, antipyretic, and anti-inflammatory effects. In the platelet, it has a more durable and sustained effect. However, while aspirin... Read more

Cardiology Management

Aspirin Efficacy - All in the Genes?

2019 25 Jul

The benefits of low-dosages of aspirin (75-100mg daily) for the secondary prevention of cardiovascular diseases (CVDs) exceed the risk of bleeding. However, most are still unclear whether aspirin has the same effects on primary prevention.   The recent results from three trials ASPREE, ASCEND and ARRIVE each tested the effects of 100mg of aspirin... Read more

Cardiology Management

Use of aspirin in individuals without cardiovascular disease

2019 24 Jan

Cardiovascular disease continues to be a leading killer in the US as well as around the globe. While the number of deaths from cardiovascular disease has reduced over the years, deaths from stroke and myocardial infarction have plateaued in the US. Since the prevalence of cardiovascular disease continues to be both a health and economic burden,... Read more

Cardiology Management

ASPREE: aspirin doesn't prolong disability-free survival in healthy seniors

2018 19 Sep

Results of the Aspirin in Reducing Events in the Elderly (ASPREE) trial indicate that aspirin use in healthy elderly persons (70 years or older) did not prolong disability-free survival over a period of five years but led to a higher rate of major haemorrhage than placebo. The findings are published online in The New England Journal of Medicine. ... Read more

Cardiology Management

Lack of Evidence for Aspirin in Heart Failure

2017 08 Aug

The WARCEF (Warfarin Versus Aspirin in Reduced Ejection Fraction) trial indicates that, compared to warfarin, aspirin does not increase the risk of hospitalisation for heart failure. The study findings contrast with those of two previous trials that showed an increase in such risk, notes an editorial published in JACC: Heart Failure. The randomised... Read more

Cardiology Management

Aspirin Does Little or Nothing for Hard Arteries

2017 12 Jun

Since decades, it is believed that aspirin reduces the risk of cardiovascular problems. However, new research from University of Florida shows that aspirin may provide little or no benefit for certain patients who have plaque buildup in their arteries. Findings are published in Clinical Cardiology. Researchers tracked the health histories of more... Read more