Search Tag: antibiotics

ICU Management

Biomarkers-in-sepsis

2023 13 Mar

This article describes the application of existing and emerging biomarkers in the diagnosis and management of sepsis and pneumonia. Introduction: The Need for  Biomarkers  in Sepsis Sepsis is defined as a dysregulated host response to infection that results in life threatening organ dysfunction. It carries an estimated...Read more

ICU Management

Antibiotic-stewardship-in-critical-and-emergency-care

2022 14 Oct

An overview of antimicrobial stewardship in critical care units and emergency departments, highlighting aspects to reduce multidrug resistance focusing on antibiotic optimisation in respiratory infections and sepsis. Introduction Infections caused by resistant bacteria are associated with higher treatment costs and increased morbidity...Read more

ICU Management

Multidrug-resistant-gram-negative-bacteria-in-the-icu

2022 14 Oct

Severe infections by antibiotic resistant gram-negative bacteria are frequent in ICU patients. They are associated with high morbidity and mortality. Introduction Bacterial infections in patients hospitalised in the Intensive Care Unit (ICU) are frequent, and they elicit an increase in morbidity and mortality. The emerging development...Read more

ICU Management

Rapid-diagnostics-and-antimicrobial-resistance-in-the-icu

2022 14 Oct

The need to address the problem of antimicrobial resistance, the importance of faster diagnosis of bacterial infections and an overview of rapid diagnostic testing. Antimicrobial resistance (AMR) is rapidly increasing on a global scale. The discovery of penicillin revolutionised the field of medicine, providing safe harbour from the most...Read more

ICU Management

Sepsis-in-critical-care-6

2022 14 Oct

The importance of clearly defining sepsis, improving early recognition strategy, and increasing the understanding of innate and adaptive immune system derangements that facilitate the development of sepsis. The improvement in mortality outcomes of patients with sepsis is attributable to the early recognition of sepsis, better adherence to guidelines,...Read more

ICU Management

The-alphabet-book-of-sepsis

2022 16 Mar

In this article, the author provides the alphabet review of sepsis and septic shock based on personal clinical experience and choice. Sepsis and septic shock have been defined in 2016 (Singer et al. 2016) and the management of patients is framed by the Surviving Sepsis Campaign guidelines with its renewed version in 2021 (Evans et al. 2021)....Read more

ICU Management

Efficacy-appropriateness-of-antibiotic-use-in-the-icu

2021 09 Nov

The frequency of antibiotic-resistant pathogens continues to increase, resulting in higher community-acquired infections and high mortality rates in critically ill patients.   In this review, the researchers critically appraise available evidence through a comprehensive literature review to investigate effective empiric antibiotic administration...Read more

ICU Management

Antibiotic-delay-intervals-mortality-among-patients-with-suspected-sepsis

2021 27 Apr

Timely delivery of antibiotics is a major cornerstone of sepsis therapy. Clinical evidence suggests that every one-hour delay in antibiotics after emergency department (ED) triage or the onset of organ dysfunction or shock could result in a 3-7% increase in the odds of a poor outcome. The Surviving Sepsis Campaign (SSC) guidelines recommend antibiotic...Read more

ICU Management

Biomarker-guided-antibiotic-stewardship-in-suspected-ventilator-associated-pneumonia

2019 15 Dec

Ventilator-associated pneumonia carries enormous morbidity and mortality, including prolonging hospital stay and increasing the cost of healthcare. In most cases, ventilator-associated pneumonia occurs without any specific signs or symptoms. Making an accurate diagnosis is often difficult. Unlike the past, the administration of empirical antibiotics...Read more

ICU Management

Procalcitonin-guided-antibiotic-therapy-in-severely-critically-ill-patients

2019 30 Aug

The controversy surrounding the efficacy of the blood infection biomarker, procalcitonin (PCT), for guidance in acute infections and sepsis treatment remains. PCT is a calcitonin precursor produced by epithelial cells when infected with bacteria and has been identified as a marker due to the protein levels’ variation upon infection initiation and cessation....Read more

ICU Management

Antibiotic-timing-and-administration-in-the-ed

2019 01 May

Antibiotics are often prescribed in the emergency department (ED) to patients with suspected infection before any definitive diagnosis can be made. However, amidst increasing antibiotic resistance, their use should be limited to those at high risk of infection or further clinical deterioration. Current tools to aid clinical decision-making include...Read more

ICU Management

Optimising-beta-lactam-treatment-in-the-icu-expert-consensus

2019 03 Apr

The French Society of Pharmacology and Therapeutics (SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (SFAR) have released guidelines on the optimisation of beta-lactam treatment in intensive care unit (ICU) patients. The two groups strongly recommend the use of personalised dosing, continuous or prolonged infusion and therapeutic...Read more

ICU Management

Results-of-the-abate-infection-trial

2019 14 Mar

According to results of the ABATE infection trial, daily bathing with an antiseptic soap, plus nasal ointment for patients with prior antibiotic-resistant bacteria reduced hospital-acquired infections among patients with central venous catheters and other devices.   The ABATE infection trial included 340,000 patients from 53 hospitals. The study...Read more

ICU Management

Highlights-from-the-i-i-i-blog-2

2018 16 Oct

(I expert, I question, I answer)  Have you got something to say? Visit  https://healthmanagement.org/c/icu/list/blog  or contact [email protected] Jean Baptiste Lascarrou Medical Intensive Care Unit, Nantes University Hospital, France @jblascarrou Epinephrine for out-of-hospital cardiac arrest “Epinephrine...Read more

ICU Management

Improving-antibiotic-initiation-for-sepsis-pre-hospital

2018 13 Sep

Sepsis is a common and costly condition encountered by pre-hospital and emergency department (ED) clinicians. Early antibiotics improve outcomes for septic patients. Researchers from Intermountain Medical Center in Utah led a study to investigate the relationship between septic patients’ pre-hospital level of care and ED door-to-antibiotic time. ...Read more

ICU Management

Antibiotic-decisions-in-the-icu-a-dragon-s-tale

2018 19 Jun

Medical decision-making about antibiotic use in critically ill patients is challenging and complex. The need for antibiotic stewardship requires judicious prescription and choice of antimicrobials, as the need for effective therapy has to be put in balance with the need to limit undue selection pressure, and all this must be done in a context of...Read more

ICU Management

Results-of-antimicrobial-stewardship-programme-implementation-in-multidisciplinary-hospital

2018 01 Jun

The interventional single-centre with historical control study was conducted in a 600-bed multidisciplinary hospital to evaluate 4 years’ results of an antimicrobial stewardship programme. We found a significant reduction in average duration of courses of antimicrobial therapy, length of stay of patients with infection in ICU, mortality in patients...Read more

ICU Management

Should-empiric-antibiotic-therapy-be-considered-old-fashioned

2018 26 Mar

The Surviving Sepsis Campaign recommends starting empiric broad-spectrum antibiotics in the initial management of patients with severe sepsis and septic shock (Rhodes et al. 2017). As a consequence, many patients receive unnecessary antibiotics, exposing them to adverse events, while others might be undertreated in spite of broad-spectrum therapy...Read more

ICU Management

New-way-to-fight-sepsis-rev-up-patients-immune-systems

2018 13 Mar

People especially those with critical illness develop sepsis when an infection triggers an overwhelming immune response, ultimately wreaking havoc on the immune system. Traditional approaches to sepsis therapy do not address the critical problem of patients' severely compromised immune systems. Now, a clinical trial demonstrates that a drug that revs...Read more

ICU Management

Time-goes-by-and-antibiotics-linger-on

2017 07 Dec

As I usually do when I'm writing, first I'll throw a random fact--not so random--with a slight relation with our subject. The thing is, I lack good metaphors. Some time ago I stumbled on a fantastic article by Holloway discussing a new approach to treating multi-drug-resistant tuberculosis . The climax is: in Switzerland, England and New York, tuberculosis-related...Read more

ICU Management

Phase-iii-study-program-with-amikacin-inhale-in-patients-with-gram-negative-pneumonia-results

2017 28 Nov

Phase III study program with Amikacin Inhale in addition to standard of care in intubated and mechanically ventilated patients with Gram-negative pneumonia does not meet primary endpoint of superiority Bayer announced on 24 November 2017 that INHALE, a global Phase III clinical study program investigating Amikacin Inhale in addition to standard of...Read more

ICU Management

Antibiotics-for-sepsis-does-each-hour-really-count

2017 31 May

"Each hour’s delay in initiating antibiotics costs lives" is a doctrine that has attained quasi-religious status. Like most (quasi-)religions this is founded more on faith and hope than hard fact, according to an article in press in the American Journal of Respiratory and Critical Care Medicine. Article author Mervyn Singer, Professor of Intensive...Read more

ICU Management

Volume-17-issue-1-2017-1

2017 16 Mar

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ICU Management

Antibiotic-resistance-in-the-icu-time-to-take-things-seriously

2017 16 Mar

  Multidrug resistance (MDR) is increasing worldwide and has been acknowledged as one of the major threats to healthcare by the World Economic Forum and the World Health Organization (World Health Organization 2014). Intensive care unit (ICU) patients seem to be particularly susceptible for acquiring MDR organisms, either just as colonisers, or as pathogens...Read more

ICU Management

Antimicrobial-stewardship-in-the-icu

2017 16 Mar

Treating patients with multidrugresistant (MDR) pathogens is an increasing challenge for intensive care unit (ICU) physicians. In the ICU, compared to other hospital departments, severe infections are most prevalent and antimicrobial use is most abundant. Not surprisingly, antimicrobial resistance (AMR) has emerged primarily in the intensive care setting, where...Read more

ICU Management

Philips-and-diagnostics-development-win-european-union-horizon-prize-better-use-of-antibiotics-1

2017 08 Feb

Philips and Diagnostics Development, a P&M Venge company, evaluate the novel human neutrophil lipocalin (HNL) biomarker for the rapid detection of bacterial infection Based on Philips’ Minicare I-20 handheld diagnostics platform, the Minicare HNL assay is recognized for its potential to provide physicians with 10-minute confirmation of bacterial...Read more

ICU Management

Volume-16-issue-4-2016-1

2016 30 Nov

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ICU Management

Prevention-and-treatment-of-vap-cochrane-reviews

2016 08 Nov

Two recent Cochrane reviews have evaluated the evidence on oral hygiene care to prevent ventilator-associated pneumonia (CAP) and antibiotics to treat it. Recommendations can be made on oral hygiene, but insufficient evidence exists for antibiotics.  See Also : Seven Days Antibiotics OK for HAP/ VAP, New Guidelines Oral Hygiene In the review...Read more

ICU Management

Volume-16-issue-3-2016-1

2016 27 Sep

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