Search Tag: antibiotic resistance

Why is the Pharmaceutical Industry Not Developing New Antibiotics?

2021 26 Nov

An overview of antibiotic resistance, causative factors, reasons for the lack of research and drug development in this area and potential solutions. Key Points Antibiotic resistance is one of the biggest threats to global health. The  primary  culprit of fuelling antibiotic resistance is the misuse and overuse of existing antibiotic... Read more

Timing of Antibiotic Therapy in the Intensive Care Unit

2021 19 Oct

Severe infections are common among patients in the ICU. According to findings from the Extended Study on Prevalence of Infection in Intensive Care III (EPIC III), 54% of the study patients had at least one suspected or proven infection on the study day, and 24% of these patients had more than one suspected or proven infection.   These infections... Read more

#ISICEM21: Advances in Resistant Gram-Negative Pneumonia

2021 03 Sep

In an interesting discussion at the 40th ISICEM International Symposium on Intensive Care & Emergency Medicine,  Richard Wunderink, Professor of Medicine, Pulmonary and Critical Care Division of Northwestern University’s Feinberg School of Medicine and Medical Director, Medical ICU, Northwestern Memorial Hospital, Chicago, discussed rising levels of... Read more

COVID-19 and Antimicrobial Stewardship

2020 19 Oct

COVID-19 is a new disease. On initial presentation, clinicians can find it difficult to differentiate between coronavirus disease and bacterial community-acquired pneumonia. COVID-19 patients often develop a hyperinflammatory phase during the disease process, which could again be difficult to distinguish from a secondary bacterial infection. That is... Read more

Biomarker-Guided Antibiotic Stewardship in Suspected Ventilator-Associated Pneumonia

2019 15 Dec

Ventilator-associated pneumonia carries enormous morbidity and mortality, including prolonging hospital stay and increasing the cost of healthcare. In most cases, ventilator-associated pneumonia occurs without any specific signs or symptoms. Making an accurate diagnosis is often difficult. Unlike the past, the administration of empirical antibiotics... Read more

Antibiotic timing and administration in the ED

2019 01 May

Antibiotics are often prescribed in the emergency department (ED) to patients with suspected infection before any definitive diagnosis can be made. However, amidst increasing antibiotic resistance, their use should be limited to those at high risk of infection or further clinical deterioration. Current tools to aid clinical decision-making include... Read more

Results of the ABATE infection trial

2019 14 Mar

According to results of the ABATE infection trial, daily bathing with an antiseptic soap, plus nasal ointment for patients with prior antibiotic-resistant bacteria reduced hospital-acquired infections among patients with central venous catheters and other devices.   The ABATE infection trial included 340,000 patients from 53 hospitals. The study... Read more

The Accelerate Pheno™ system in clinical practice: fast and accurate turnaround for critical results

2018 01 Jun

Our clinical experiences of using the Accelerate Pheno™ system have greatly benefited patient care, providing earlier diagnostic certainty. Two complex sepsis cases are discussed, where the impact of rapid identification, with antibiotic sensitivities, of the causative organism from blood cultures is described. At Hampshire Hospitals NHS... Read more

ICU Management

2018 26 Mar

The Surviving Sepsis Campaign recommends starting empiric broad-spectrum antibiotics in the initial management of patients with severe sepsis and septic shock (Rhodes et al. 2017). As a consequence, many patients receive unnecessary antibiotics, exposing them to adverse events, while others might be undertreated in spite of broad-spectrum therapy... Read more