Search Tag: Sepsis

ICU Management

Imaging-the-critically-ill

2022 08 Dec

Imaging is integral to managing critically ill patients in the ICU as it is a key source of diagnostic information to guide clinical decision-making. In recent years, there has been significant evolution in the field of critical care imaging with an increased focus on improving imaging modalities and methodologies and increasing access to imaging...Read more

ICU Management

The-clinical-utility-of-estimated-plasma-volume-in-critical-care

2022 08 Dec

An overview of clinical evidence that demonstrates the prognostic value of estimated plasma volume (ePVS) in critically ill patients. Relevance Plasma volume (PV) is the total volume of blood plasma – the extracellular fluid volume of the vascular space. It is associated with regulating interstitial and intravascular spaces; hence it can...Read more

ICU Management

Guiding-clinical-care-using-pancreatic-stone-protein-1

2022 08 Dec

The role of point-of-care testing in the early identification and management of sepsis, the need for better markers to identify sepsis, an overview of the Pancreatic Stone Protein (PSP) and clinical evidence highlighting its effectiveness as a biomarker. Pancreatic Stone Protein Infections are a leading cause of morbidity and mortality...Read more

Sepsis

Pancreatic-stone-protein-for-predicting-perioperative-infection-in-cardiac-surgery

2022 06 Dec

According to the Surviving Sepsis Campaign (SSC), sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The organ dysfunction may be transitory in some patients, but complications can always occur in others. For example, a patient who has undergone cardiac surgery can present postoperative cardiac dysfunction,...Read more

Sepsis

Amr-dilemma-to-give-or-not-to-give-antibiotics

2022 24 Nov

The two primary reasons for using antibiotics are treating and preventing bacterial infections. However, a leading cause of the overuse of antibiotics is the misdiagnosis of sepsis. Early and accurate diagnostics using point-of-care biomarkers can help address this issue.    Sepsis is a dysregulated reaction of the body to infection. It is a...Read more

Sepsis

Psp-for-early-diagnosis-of-post-operative-peritonitis-intra-abdominal-infection-sepsis

2022 24 Nov

Intra-abdominal infections, postoperative peritonitis, sepsis, septic shock and multiple organ failure have high mortality in the ICU (at nearly 30%) and require complex management and multiple surgical interventions.  The following case report demonstrates the use of serial pancreatic stone protein (PSP) measurements, a biomarker of infection...Read more

Sepsis

Genome-wide-association-study-of-patients-with-sepsis

2022 09 Nov

Sepsis is a systemic inflammatory response to infections accompanied by organ dysfunction. Sepsis has a high mortality rate of about 30%. Approximately 189 cases of sepsis per 100,000 people are reported per year. Many genetic studies have identified gene variants associated with the development and outcomes of sepsis.  In this study, the researchers...Read more

Sepsis

Vingmed-symposium-identification-of-sepsis-up-to-72-hrs-in-advance-psp-a-new-biomarker-of-sepsis

2022 01 Nov

On September 21st during the Clinical Chemistry congress on Jönköping, Sweden, Dr. Francois Ventura, Intensive Care Physician and Chief Medical Officer gave an academic lecture addressing the disease burden of sepsis and antimicrobial resistance (AMR), and the place of biomarkers in the management of sepsis and how they could help improve the management...Read more

Sepsis

Remote-ischaemic-conditioning-in-septic-shock

2022 25 Oct

Septic shock is one of the most severe complications of any infection. It affects millions of people each year. Studies show that in the U.S. and Europe, nearly 10% of patients admitted to the ICU have septic shock. Significant efforts have been made to recognise and treat septic shock early. Still, over 50% of patients die of septic shock within days...Read more

Sepsis

Abionic-webinar-guiding-clinical-care-using-pancreatic-stone-protein

2022 18 Oct

The role of Point-of-Care Testing in the Early Identification and Management of Sepsis   Introduction & Welcome On September 22nd, over 240 attendees from all over the world had the opportunity to connect and tune into this educational session along with interactive roundtable discussions, chaired and moderated by Prof. Jean-Louis Vincent,...Read more

Sepsis

World-sepsis-day

2022 11 Oct

The Global Sepsis Alliance (GSA) and the Sepsis Stiftung joined together to celebrate 10 years of World Sepsis Day on 16 September 2022 in Berlin, under the theme of " Making Sepsis a National and Global Health Priority ”. The event aimed to engage with high-level policy makers, representatives of health authorities, patient organizations, health...Read more

Sepsis

Source-control-and-sepsis-management

2022 27 Sep

Source control is important in the treatment of sepsis and septic shock. Lack or delay of source control can result in worse outcomes for patients.   The 2021 Surviving Sepsis Campaign guidelines recommend identifying the anatomical source of infection that requires source control and implementing it as soon as possible. However, adequate source...Read more

Sepsis

World-sepsis-day-making-sepsis-a-national-and-global-health-priority-1

2022 05 Sep

World Sepsis Day was inaugurated exactly ten years ago and, since then, has made great progress in the fight against sepsis. Sepsis awareness has increased across the globe. However, sepsis still accounts for approximately 11 million lives lost every year around the world. This does not include millions of deaths by viral sepsis due to COVID-19. ...Read more

Sepsis

Crt-kinetics-after-fluid-infusion

2022 29 Aug

Peripheral tissue hypoperfusion is a strong predictor of poor outcomes in patients suffering from severe conditions, such as sepsis, cardiac arrest or cardiogenic shock. The evaluation of peripheral tissue perfusion is very important in identifying shock patients. This can be done at the bedside with either semi-quantitative tools such as the mottling...Read more

Sepsis

Reversing-sepsis-induced-hypotension

2022 25 Aug

Sepsis is characterised by hypovolaemia and vasodilation. It is also characterised by organ dysfunction secondary to a dysregulated immune response of the host to the microbial pathogen. Prompt identification, early treatment with appropriate antibiotics, and fluid resuscitation can improve patient outcomes. Patients with cirrhosis and sepsis are a...Read more

Sepsis

Role-of-no-pathway-in-sepsis

2022 25 Aug

Sepsis and septic shock are accompanied by haemodynamic, microcirculatory and metabolic changes. These changes can lead to impaired tissue oxygenation, multiorgan damage and death. A common hallmark of sepsis is reduced blood pressure. An increase in nitric oxide (NO) because of inflammation can contribute to vasodilation. On the other hand, a decrease...Read more

Sepsis

Abionic-receives-ivdr-certification-for-its-predictive-ultra-rapid-sepsis-test

2022 09 Aug

BSI certification agency has granted Abionic’s abioSCOPE® device and PSP test the IVDR certification for in-vitro diagnostics. This certification complies with Europe’s new In-vitro Diagnostic Regulation (IVDR), and will be required for products sold within the EU from May 2022 onward. A transitional regulation allows established, non-IVDR-certified...Read more

Sepsis

Pancreatic-stone-protein-testing-reduces-expenditure-in-sepsis

2022 02 Aug

Sepsis is a life-threatening organ dysfunction and a cause of significant morbidity and mortality. In addition, the high number of sepsis cases is a significant economic burden for healthcare systems. Statistics show that sepsis was the most expensive condition treated in the U.S. in 2013, costing nearly $24 billion. An analysis of Medicare claims...Read more

Sepsis

Venous-thromboembolism-in-sepsis

2022 02 Aug

Septic patients are often affected by coagulation disorders. Hence, they are at a high risk of thrombotic complications, ranging from widespread microvascular involvement, such as disseminated intravascular coagulation, to venous thromboembolism, arising as deep vein thrombosis or pulmonary embolism. Over the years, knowledge about the interconnected...Read more

Sepsis

Sepsis-awareness-patient-public-and-healthcare-professionals

2022 19 Jul

Sepsis is a preventable cause of death. Early recognition, diagnosis, and appropriate clinical management can prevent sepsis and improve outcomes. However, the condition is not widely recognised by patients and the general public. In addition, knowledge gaps also persist among healthcare professionals.  Increasing knowledge and awareness of sepsis,...Read more

Sepsis

Accuracy-of-pancreatic-stone-protein-for-diagnosis-of-infection

2022 12 Jul

Severe infections cause significant morbidity and mortality among hospitalised patients. Early detection of life-threatening infections is crucial to improving outcomes. However, none of the circulating blood biomarkers that have been investigated have been found to detect life-threatening infection quickly or accurately. Despite sub-optimal results,...Read more

Sepsis

Trends-in-antimicrobial-prescribing-during-hospitalisation-for-sepsis

2022 05 Jul

There have been concerns that the emphasis on rapid administration of antimicrobials for sepsis may result in an increase in the overall use of antimicrobials, even in patients without sepsis. In a study of 1,559,523 patients hospitalised at 152 hospitals in two health care delivery systems, researchers aimed to determine whether shortening the...Read more

Sepsis

Serial-measurement-of-pancreatic-stone-protein-for-detection-of-sepsis

2022 27 Jun

Sepsis continues to be a challenging health problem associated with high morbidity and mortality. Approximately 48.9 million cases of sepsis were recorded worldwide in 2017, with 11 million related deaths. Sepsis guidelines emphasise the early recognition and aggressive management of this condition with early antibiotic treatment and support. If not...Read more

Sepsis

Intravenous-vitamin-c-in-icu-patients-with-sepsis

2022 21 Jun

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis contributes to between a third and a half of deaths in hospitals. It is responsible for nearly 11 million deaths worldwide each year. Treatment of sepsis typically includes antimicrobial therapy, source control, and organ support. It is believed...Read more

Sepsis

Renal-replacement-therapy-in-patients-with-sepsis-associated-aki

2022 20 Jun

Acute kidney injury (AKI) is a serious complication of sepsis. According to data from several clinical studies, AKI can occur in nearly 50% of patients with sepsis and has a mortality rate of approximately 60% at three months.  Renal replacement therapy (RRT) is used to treat AKI, but some data show that it exerts only a limited effect in patients...Read more

Sepsis

Therapeutic-hyperthermia-and-survival-in-afebrile-sepsis-patients

2022 14 Jun

Fever is an important feature of infection. However, fewer than half of patients with sepsis present with fever at the time of diagnosis. Afebrile sepsis patients have nearly twice the mortality and are at a higher risk of developing secondary infections than patients with fever.  Fever is an adaptive response to infection that may be critical...Read more