Search Tag: Biomarkers
2024 09 Apr
Traumatic brain injury (TBI) is a major cause of death and disability globally, with outcomes heavily influenced by both the severity of the initial injury and subsequent secondary injury mechanisms. Systemic insults (SIs), such as hypoxaemia and hypotension, can worsen outcomes by exacerbating the cascade of events following the initial damage....Read more
2023 13 Oct
An overview of ionised serum magnesium as an important biomarker for critically ill patients and how iMg testing is utilised at Mater Intensive Care. Ionised Serum Magnesium - An Important Biomarker Magnesium is the fourth most common cation in the body and the second most abundant intracellular cation, exceeded only by potassium....Read more
2023 13 Oct
Hospital and ICU nosocomial sepsis screening for acutely ill and high-risk patients and daily measurement of PSP to diagnose nosocomial sepsis three to five days before the onset of symptoms. Introduction Sepsis is a major public health threat and is responsible for 11 million deaths per year (Rudd et al. 2020) among 48.9 million cases....Read more
2023 20 Apr
An overview of promising biomarkers in critical care, characteristics a biomarker should have and how to ensure their usefulness in clinical practice. Introduction Precision medicine is a medical approach that tailors treatments based on individual patient characteristics and their unique response to therapies for a particular disease....Read more
2023 13 Mar
Biomarkers are quantifiable indicators of physiological or pathological processes in the body. They can be useful in establishing a diagnosis, assessing disease progression and a patient's condition and guide therapeutic interventions. However, a great deal could still be done to further improve the utilisation of biomarkers in critical care....Read more
2023 13 Mar
Despite several biomarkers having been studied for diagnosis and/or prognosis of acute respiratory distress syndrome (ARDS), their extensive use has not been established. Better knowledge of the pathophysiology of ARDS and acute lung injury (ALI) may help develop new biomarkers. Acute respiratory distress syndrome (ARDS) is characterised by...Read more
2023 13 Mar
This article describes the application of existing and emerging biomarkers in the diagnosis and management of sepsis and pneumonia. Introduction: The Need for Biomarkers in Sepsis Sepsis is defined as a dysregulated host response to infection that results in life threatening organ dysfunction. It carries an estimated...Read more
2023 13 Mar
Biomarkers are an area of rapid discovery in critical care medicine today. They have the potential to improve our ability to identify and manage patients at increased risk of organ failure and death. This article provides an overview of biomarkers of infection in the intensive care unit. The heterogeneity of sepsis makes its identification...Read more
2023 13 Mar
A biomarker defines a measurable indicator of a patient's medical situation that can be measured precisely and accurately. Biomarkers provide value for diagnosis, prognosis, early disease detection, risk stratification, suitable treatment (theragnostic), and trial improvement for patients with sepsis or presumed sepsis. Introduction...Read more
2023 13 Mar
Abstract Sepsis and antimicrobial resistance are two major public health problems . Sepsis is defined as a dysregulated response of the body to a bacterial infection with organ dysfunction . The 2021 Surviving Sepsis Campaign SSC guidelines proposed characterising the infection based on clinical assessment and the dysregulated...Read more
2023 13 Mar
Biomarkers are quantifiable indicators of physiological or pathological processes in the body. They can be more effectively utilised in intensive care by improving standardised protocols for biomarker testing and interpretation. Join our panellists as they discuss the use of Biomarkers in critical care and where and how biomarkers can provide valuable...Read more
2021 23 Mar
Early recognition of sepsis is vital for improving patient outcomes. If detected on time, sepsis can be treated with antibiotics and source control, recognition and reversal of shock and organ support. The three most common organ dysfunctions in sepsis are cardiovascular, renal and respiratory. Cardiovascular and respiratory organ dysfunctions are...Read more
2020 24 Nov
The laboratory plays a critical role in ensuring optimal outcomes for ICU patients. Several biomarkers are valuable in this context and can help clinicians achieve improved patient outcomes and decreased expenses for healthcare. I mproving both in-ICU and post-ICU clinical outcomes often depends on actions taken much sooner in a patient’s...Read more
2020 13 Jun
Sepsis biomarkers have an important role in the diagnosis, prognosis, and treatment of sepsis management. If timely and accurate information about biomarkers becomes available, the physician can not only make better therapeutic choices but also monitor the efficacy of the intervention in progress and adjust it accordingly. In a previous review...Read more
2019 28 Dec
As we move into 2020, here's a quick recap of our most clicked stories in ICU in 2019: Using Biomarkers for Mortality Prediction in Patients With Sepsis A new study evaluated the prognostic value of six biomarkers at onset of sepsis in adult patients with sepsis or septic shock. Risk Factors for Frailty and Death in the ICU...Read more
2019 25 Jul
Existing biomarkers provide limited use for rapid detection of sepsis since they cannot accurately distinguish sepsis from other common conditions encountered in the emergency department (ED). Now a U.S. clinical trial suggests that the monocyte distribution width (MDW) can be a useful indicator of Sepsis-2 and Sepsis-3 in high-risk ED patients. "Changes...Read more
2019 01 May
Antibiotics are often prescribed in the emergency department (ED) to patients with suspected infection before any definitive diagnosis can be made. However, amidst increasing antibiotic resistance, their use should be limited to those at high risk of infection or further clinical deterioration. Current tools to aid clinical decision-making include...Read more
2019 12 Mar
Since sepsis was first identified almost three decades ago, the existing definitions remain imprecise and the clinical diagnosis of sepsis corresponds poorly with post hoc presence of infection. Furthermore, the outcome of sepsis depends on factors beyond patient signs and symptoms, including age, the infection source, and the timing and appropriateness...Read more
2018 16 Mar
An overview of the recent advances in the diagnosis and treatment of immune system dysfunction in sepsis. Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection (Singer et al. 2016). Sepsis-induced immune system dysfunction is an important sequelae of sepsis. The persistence of immune system dysfunction...Read more
2016 03 Aug
The intensive care infection score (ICIS) has potential as a biomarker for infection, according to a study published in critical care. is derived from 5 blood-cell derived parameters that characterise the innate immune response in routine blood samples. Patrick J van der Geest, Erasmus Medical Center, the Netherlands, and colleagues report on the...Read more
2016 12 Jul
A test that uses three biomarkers of neutrophil function on the day of a major burns injury to determine which patients are likely to become septic showed a 98.6 percent certainty. The data highlight burn-induced neutrophil dysfunction and immature granulocyte (IG) release as a potential therapeutic target to reduce susceptibility to bacterial infections...Read more
2016 30 May
Where Are We Now? Acute kidney injury (AKI) has been recognised as a major public health problem. It affects >50% of patients in the Intensive Care Unit (ICU) and is associated with serious short- and long-term complications, premature death and high financial healthcare costs (Mehta et al. 2015; Hoste et al. 2015; Lewington et al. 2013). The consensus...Read more
2016 30 May
penKid – A Dynamic Inflammation-Independent Biomarker Of Kidney (Dys)function Early recognition and close monitoring of acute kidney injury (AKI) is vital in the ICU, given AKI’s high prevalence and effect on length of stay and risk of re-hospitalisation and death (McCullough et al. 2013). As more becomes known about biomarkers, intensivists need...Read more