Cardica designs and manufactures proprietary stapling devices for surgical procedures. Cardica's stapling technology is designed to minimize operating time and to enable minimally-invasive and robot-assisted surgeries.

The company manufactures its automated anastomosis systems, the C-Port Distal Anastomosis Systems and PAS-Port Proximal Anastomosis System, for coronary artery bypass graft (CABG) surgery and has shipped over 25,000 units throughout the world. In addition, Cardica is developing the Cardica Microcutter, a true multi-fire endoscopic stapling device designed to be used in a variety of procedures, including bariatric, thoracic and general surgery.