Industry veteran brings deep experience in neuroscience and design of brain penetrant molecules, including at Janssen (Johnson & Johnson), to neuro drug discovery efforts


Herophilus, a leading biotechnology company developing neurotherapeutics to cure complex brain diseases, has announced the appointment of Brad Savall, Ph.D. as the company’s new Vice President and Head of Chemistry. Dr. Savall brings to Herophilus over 20 years of experience in medicinal chemistry, including the design of molecules optimized for brain diseases, as the company continues to progress their pipeline of novel drugs for neurological and psychiatric disease.


Prior to joining Herophilus, Dr. Savall served as Director of Medicinal Chemistry at Plexium where he led efforts to leverage the company’s phenotypic screening platform in order to discover novel monovalent degraders. Prior to Plexium, he served as the Associate Director of Drug Discovery at Sanford Burnham Prebys Medical Discovery Institute, leading medicinal chemistry and drug discovery efforts on multiple early and mid-stage drug discovery programs. Dr. Savall was also previously employed at Janssen (Johnson & Johnson) where he led projects for three drug discovery programs that delivered four clinical candidates across neuroscience and immunology.


“Herophilus is surpassing the limitations of traditional neuroscience drug discovery methods with a powerful new approach that has the potential to enable transformative neurotherapeutics,” said Dr. Savall. “I am thrilled to be joining this groundbreaking effort to discover new medicines that will impact the lives of millions living with complex brain disease.”


Starting with patient-derived stem cells, Herophilus develops brain organoids that uniquely recapitulate characteristics of human brain disease, allowing researchers to identify drug compounds with significantly increased confidence of clinical efficacy compared to those found using standard approaches. Robotic automation allows the company to develop organoids at massive scale and gather rich multi-modal data, while advanced machine learning applied to the data unlocks novel insights into neurological disease. In contrast to traditional single target-focused drug discovery, Herophilus’s technology yields robust drug candidates, identifies polypharmacologic drugs and combination therapies, and ultimately enables systematic drug discovery for complex brain diseases.


“Brad is an accomplished scientist with a stellar track record of solving the challenges of drug discovery,” said Saul Kato, Ph.D., co-founder and CEO of Herophilus. “We are excited to welcome him to the Herophilus team as we continue to advance our vision of reinventing neuro drug discovery and create a new era of curative therapeutics for complex brain diseases.”


The appointment of Dr. Savall follows the addition of Sharath Hegde, Ph.D. as Chief Scientific Officer and Kenneth Kosik, M.D. to the company's Scientific Advisory Board.


Source: Herophilus

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Herophilus, biotechnology, neurotherapeutics,complex brain diseases,Brad Savall, Vice President,Head of Chemistry Herophilus, a leading biotechnology company developing neurotherapeutics to cure complex brain diseases, has announced the appointment of Brad Savall, Ph.D. as the company’s new Vice President and Head of Chemistry.