The study, led by Beata Mickiewicz and colleagues from the University of Calgary and University of Alberta, took serum and plasma samples from children aged 1-23 months presenting with sepsis to the PICU (n=46) or who presented to the paediatric emergency department with (n=58) and without sepsis (n=19).
You might also like: What's new in sepsis in children?
The results were compared to previously published results for older children aged 2-17 years old. Seven metabolites and their concentration changes common to both groups were used to create the sepsis triage model: increased level of dimethylamine, mannose, 3-methyl-2-oxovalerate and 3-hydroxyisovalerate, and decreased concentrations of alanine, O-acetylcholine and acetate. None of the inflammatory protein-mediators were common to both groups. The biopattern was internally validated and requires further validation.
These seven metabolites can be described as a biopattern for sepsis triage in children, say the researchers, and could potentially inform triage in the ED, as it reflects altered energy metabolism in children most affected by sepsis.
Image credit: iStock